KMID : 1161420200230090905
|
|
Journal of Medicinal Food 2020 Volume.23 No. 9 p.905 ~ p.919
|
|
Nigella sativa and Trigonella foenum-graecum Supplemented Chapatis Safely Improve HbA1c, Body Weight, Waist Circumference, Blood Lipids, and Fatty Liver in Overweight and Diabetic Subjects: A Twelve-Week Safety and Efficacy Study
|
|
Rao Amit S.
Hegde Shyamala Pacioretty Linda M. DeBenedetto Jan Babish John G.
|
|
Abstract
|
|
|
In 2019, ¡?463 million people globally had diabetes mellitus (DM), with China (25.1%), India (16.6%), and the United States (6.69%) representing nearly 50% of that total. The primary objectives of this exploratory study were to assess the safety and potential efficacy of Nigella sativa and fenugreek seed supplemented chapatis in overweight (OW) and type 2 DM subjects. Forty subjects (15/OW; 9/DM; 16/DM/OW) consumed two chapatis twice a day 6 days/week for a daily dose of 5.45?g of an N. sativa/fenugreek combination over 12 weeks with no changes in lifestyle or medications. Anthropometric, glycemic, and vascular variables were recorded at baseline and after 6 and 12 weeks. Glycated hemoglobin (HbA1c), plasma lipids, and complete metabolic profile were measured at baseline and termination. Compliance, estimated during twice-daily individual delivery of precooked chapatis, was 100%, with no significant adverse effects. At termination, body weights, body mass index, waist and hip circumferences, index of central obesity, HbA1c, fasting blood glucose, 2-h postprandial blood glucose, estimated average glucose over 12 weeks, total cholesterol (TC), non-high density lipoprotein (HDL) cholesterol, very low density lipoprotein (VLDL), and triglycerides (TG) were decreased (P?.05) over all subjects. Subjects with HbA1c ¡Ã7.0 exhibited greater improvements in all glycemic variables than HbA1c <7.0 subjects. In addition, the decrease in HbA1c was positively correlated with decreases in (1) hepatic enzymes alkaline phosphatase (r?=?0.301, P?=?.0067) and aspartate transaminase (r?=?0.277, P?=?.0129), (2) systolic blood pressure (r?=?0.388, P?=?.0004), and (3) number of diagnostic metabolic syndrome criteria exhibited per subject (r?=?0.391, P?=?.0005), cardiovascular risk score (CRS) (r?=?0.281, P?=?.0115), and hepatic steatosis index (HSI) (r?=?0.223, P?=?.0467). Atherogenic and diabetogenic indexes TC/HDL, low density lipoprotein/HDL, VLDL/HDL, and TG/HDL were all decreased (P?.05). Among all subjects, improvement (P?.05) was seen in CRS (?10.7%), fatty liver index (?19.8%), lipid accumulation product (?13.8%), and HSI (?7.53%). N. sativa/fenugreek supplemented chapatis present a safe and seamless dietary modification to address cardiometabolic risk.
|
|
KEYWORD
|
|
hepatic steatosis, Nigella sativa, obesity, Trigonella foenum-graecum, type 2 diabetes
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|